The last proposed mechanism of RBC vasodilation within the existence of nitrite could be the reduction of nitrite to NO by Hb. Brooks 1st analyzed the nitrite Hb conversation in 1937 which do the job was afterwards prolonged by Doyle in 1981 (Brooks, 1937; Doyle et al., 1981). Nitrite reacts with deoxygenated Hb to sort metHb and NO (Brooks, 1937;